Protein Details: Neuronal acetylcholine receptor subunit eat-2

Function

Ionotropic receptor with a probable role in the modulation of auditory stimuli. Agonist binding may induce an extensive change in conformation that affects all subunits and leads to opening of an ion-conducting channel across the plasma membrane. The channel is permeable to a range of divalent cations including calcium; the influx of which may activate a potassium current which hyperpolarizes the cell membrane. In the ear; this may lead to a reduction in basilar membrane motion; altering the activity of auditory nerve fibers and reducing the range of dynamic hearing. This may protect against acoustic trauma. .

Sequence

PDB Structures

Ligand Binding